abstract：BACKGROUND:Although prostaglandin D2 (PGD2), a mast cell-derived inflammatory mediator, may trigger allergic airway inflammation, its potency and the mechanism by which it induces airway microvascular leakage, a component of airway inflammation, is not clear. OBJECTIVE:We wanted to evaluate the relative potency of PGD...

journal_title：Prostaglandins & other lipid mediators

authors： Nishimura H,Tokuyama K,Inoue Y,Arakawa H,Kato M,Mochizuki H,Morikawa A

更新日期：2001-08-01 00:00:00

abstract：:We examined the disruptive effect of highly selective agonists for prostaglandin E2 receptor subtypes (EP1, EP2, EP3 and EP4) on the blood-aqueous barrier, and evaluated the inhibitory effect of tetramethylpyrazine, an active component of Ligusticum wallichii, on the elevation of aqueous flare induced by the EP agonis...

journal_title：Prostaglandins & other lipid mediators

authors： Kitagawa K,Hayasaka S,Watanabe K,Nagaki Y

更新日期：2001-07-01 00:00:00

abstract：:Iloprost is a stable prostacyclin analog commonly employed in the treatment of peripheral vascular disease and also indicated in the treatment of patients affected by systemic sclerosis (SSc) in the presence of severe Raynaud's phenomenon (RP). Several mechanisms of action of the drug other than vasodilation and antip...

journal_title：Prostaglandins & other lipid mediators

authors： Della Bella S,Molteni M,Mocellin C,Fumagalli S,Bonara P,Scorza R

更新日期：2001-06-01 00:00:00

abstract：:Sphingosine 1-phosphate (Sph-1-P) is a bioactive sphingolipid, acting both as an intracellular second messenger and extracellular mediator, in mammalian cells. In cell types where Sph-1-P acts as an intracellular messenger, stimulation-dependent synthesis of Sph-1-P, possibly resulting from sphingosine (Sph) kinase ac...

journal_title：Prostaglandins & other lipid mediators

authors： Yatomi Y,Ozaki Y,Ohmori T,Igarashi Y

更新日期：2001-04-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (SPP) are lipid mediators released upon platelet activation. The concentration of LPA in serum is estimated at 1-10 microM whereas the concentration in plasma is considerably less. The SPP concentration in serum is 0.5 microM, approximately two-fold higher than t...

journal_title：Prostaglandins & other lipid mediators

authors： Panetti TS,Magnusson MK,Peyruchaud O,Zhang Q,Cooke ME,Sakai T,Mosher DF

更新日期：2001-04-01 00:00:00

abstract：:Prostaglandin F2alpha (PGF2alpha) is a major physiological luteolysin in the cow. However, injection of PGF2alpha before day 5 (day 0 = estrus) of the estrous cycle dose not induce luteolysis. On the other hand, the early corpus luteum (CL) actively produces PGF2alpha. This indicates that luteal PGF2alpha may play a k...

journal_title：Prostaglandins & other lipid mediators

authors： Kobayashi S,Miyamoto A,Berisha B,Schams D

更新日期：2001-01-01 00:00:00

abstract：:Ultraviolet B (UVB) radiation causes much of the cutaneous damage after both acute and long-term exposure, and is also the most important etiologic agent in human skin cancer. UVB exposure initially induces an inflammatory response characterized by edema, dermal infiltration of leukocytes, sunburn cell formation, as w...

journal_title：Prostaglandins & other lipid mediators

authors： Wilgus TA,Ross MS,Parrett ML,Oberyszyn TM

更新日期：2000-10-01 00:00:00

abstract：:Previous studies have demonstrated that cerebral ischemia stimulated the increased abundance of immunoreactive PGHS-2, but not PGHS-1, in brain tissue homogenates in late-gestation fetal sheep. The goal of the present study was to detect PGHS-1 and PGHS-2 mRNA in specific fetal brain regions, and to semi-quantitativel...

journal_title：Prostaglandins & other lipid mediators

authors： Tong H,Dhillon H,Wood CE

更新日期：2000-07-01 00:00:00

abstract：:In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the pro...

journal_title：Prostaglandins & other lipid mediators

authors： Burstein SH,Rossetti RG,Yagen B,Zurier RB

更新日期：2000-04-01 00:00:00

abstract：:The thromboxane A2/prostacyclin (TX/PGI) ratios were measured in patients with renal diseases to elucidate the relationship between the ratios and the pathological changes of the diseases. Urinary stable metabolites of thromboxane A2 and prostacyclin, 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-prostaglandin F1alph...

journal_title：Prostaglandins & other lipid mediators

authors： Hishinuma T,Koseki Y,Katayama J,Murai Y,Saito T,Mizugaki M

更新日期：2000-01-01 00:00:00

abstract：:Prostacyclin has a vasodilating effect on pulmonary vessels, whereas thromboxane A2 results in vasoconstriction. This study was designed to test the hypothesis that recurrent central apneas in preterm infants are correlated with a reduced prostacyclin to thromboxane A2 ratio. Twelve preterm infants with clinical event...

journal_title：Prostaglandins & other lipid mediators

authors： Hoch B,Bernhard M

更新日期：1999-11-01 00:00:00

abstract：:The partially purified phospholipid hydroperoxide glutathione peroxidase (PHGPx) from A431 cells was used to systematically compare the inhibitory effect on the enzyme activity of various lipoxygenases and cyclooxygenases. Under the standard assay system, platelet 12-lipoxygenase, 15-lipoxygenase, and cyclooxygenase-2...

journal_title：Prostaglandins & other lipid mediators

authors： Huang HS,Chen CJ,Suzuki H,Yamamoto S,Chang WC

更新日期：1999-10-01 00:00:00

abstract：:We devised an effective purification for the microdetermination of prostaglandin E2 (PGE2) in human joint fluid using gas chromatography/selected ion monitoring and determined PGE2 in the joint fluid in rheumatoid arthritis (RA) patients using this method. The methyl estermethoxime-tert-butyldimethylsilyl ether deriva...

journal_title：Prostaglandins & other lipid mediators

authors： Hishinuma T,Nakamura H,Sawai T,Uzuki M,Itabash Y,Mizugaki M

更新日期：1999-10-01 00:00:00

abstract：:Arachidonic acid (AA) mobilization by phospholipase A2 (PLA2) and subsequent prostaglandin synthesis is considered to be a pivotal event in inflammation. The purpose of this study was to assess the efficacy of a Type II PLA2 specific inhibitor, SB 203347, in reducing prostaglandin production in Type II PLA2-transfecte...

journal_title：Prostaglandins & other lipid mediators

authors： Munns MJ,King RG,Rice GE

更新日期：1999-07-01 00:00:00

abstract：:The objective of this study was to evaluate the influence of smoking on F2-isoprostanes, prostacylin and nitric oxide in human umbilical vessels. Umbilical cords from 13 babies of smoking mothers and from 28 babies of non-smoking mothers were examined for levels of F2-isoprostanes, prostacyclin, L-arginine, and L-citr...

journal_title：Prostaglandins & other lipid mediators

authors： Obwegeser R,Oguogho A,Ulm M,Berghammer P,Sinzinger H

更新日期：1999-06-01 00:00:00

abstract：:Proteinuria is currently considered a very sensitive predictor of diabetic nephropathy, but 20-25% of all diabetic patients with negative Albustix reaction excrete higher than normal (< 20 mg/24 h) amounts of albumin in their urine. It is our hypothesis that platelet-activating factor (PAF), a potent glycerophospholip...

journal_title：Prostaglandins & other lipid mediators

authors： Kudolo GB,DeFronzo RA

更新日期：1999-05-01 00:00:00

abstract：:We showed that human adult red blood cells (RBCs) produce prostaglandin E1 (PGE1) and E2 (PGE2). RBCs that were mechanically stressed in the presence of extracellular Ca2+ by being injected rapidly through a fine needle produced PGE1 and PGE2 within 30 min after this mechanical stress. The amounts of PGE1 and PGE2 pro...

journal_title：Prostaglandins & other lipid mediators

authors： Oonishi T,Sakashita K,Ishioka N,Suematsu N,Shio H,Uyesaka N

更新日期：1998-06-01 00:00:00

abstract：:The aim of this study was to investigate and clarify the role of prostaglandins (PG) on fat cell lipolysis in female rats. Incubations with adenosine deaminase (ADA) were used for the deamination of endogenous adenosine and increased basal (155%) and isoproterenol (10(-9) M) (348%) stimulation of glycerol release from...

journal_title：Prostaglandins & other lipid mediators

authors： Girouard H,Savard R

更新日期：1998-05-01 00:00:00

abstract：:Platelet-activating factor (PAF) is an important lipid involved in inflammation reaction and circulation regulation. The receptor for human PAF is synthesized from two spliced transcripts of the same gene. Our observation in the present study shows that HUVEC express transcript-1 only in the static condition. Shear st...

journal_title：Prostaglandins & other lipid mediators

authors： Okahara K,Sun B,Kawasaki T,Monden M,Kambayashi J

更新日期：1998-04-01 00:00:00